반응 #75788

반응 방정식

1,1-Dimethylethyl N-[1-({[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]amino}carbonyl)-3-methylbutyl]carbamate

sodium hydroxide

→

N1-[2-(4-Amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-2-amino-4-methylpentanamide

용매

hydrochloric acid

반응 조건

후처리

1. 1
   온도heated on a steam bath for 30 minutes
2. 2
   온도to cool
3. 3
   기타The resulting precipitate was isolated by filtration
4. 4
   기타dried
5. 5
   기타to provide 0.15 g of N1-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-2-amino -4-methylpentamide as a white solid, m.p.60-65° C

실험 절차

1,1-Dimethylethyl N-[1-({[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]amino}carbonyl)-3-methylbutyl]carbamate (0.35 g, 0.7 mmol) was combined with 1 N hydrochloric acid (40 mL) and heated on a steam bath for 30 minutes. The reaction mixture was allowed to cool and then it was made basic with 10% sodium hydroxide. The resulting precipitate was isolated by filtration and dried to provide 0.15 g of N1-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-2-amino -4-methylpentamide as a white solid, m.p.60-65° C. Analysis: Calculated for C21H31N7O: %C, 63.27; %H, 7.86; %N, 24.66. Found: %C, 62.27; %H, 7.67; %N, 24.77. HRMS (EI) calcd for C21H31N7O (M+) 397.2590 found 397.2582.

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