반응 #75778

반응 방정식

1,1-Dimethylethyl N-{2-[(3-nitro[1,5]naphthyridin-4-yl)amino]ethyl}carbamate

→

1,1-dimethylethyl N-{2-[(3-amino[1,5]naphthyridin-4-yl)amino]ethyl}carbamate

수율 100.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   기타to remove the catalyst
3. 3
   농축The filtrate was concentrated under vacuum

실험 절차

1,1-Dimethylethyl N-{2-[(3-nitro[1,5]naphthyridin-4-yl)amino]ethyl}carbamate (10 g, 0.03 mol), ethyl acetate (800 mL) and platinum on carbon catalyst were combined in a Parr bottle and then the mixture was hydrogenated overnight. The reaction mixture was filtered to remove the catalyst. The filtrate was concentrated under vacuum to provide 9.1 g of 1,1-dimethylethyl N-{2-[(3-amino[1,5]naphthyridin-4-yl)amino]ethyl}carbamate as a yellow syrup. Analysis: Calculated for C15H21N5O2+0.1 CH3CO2C2H5: %C, 59.25; %H, 7.04; %N, 22.43. Found: %C, 58.96; %H, 6.87; %N, 22.46.

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