반응 #7577

반응 방정식

sodium hydroxide

4-fluoro-2-methyl-5-nitrophenol

→

2-fluoro-5-hydroxy-4-methylaniline

수율 47.0%

용매

water

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 4 hours
3. 3
   온도to cool
4. 4
   추출extracted with ethyl acetate (100 ml)
5. 5
   추출The ethyl acetate extract
6. 6
   건조was dried (MgSO4)
7. 7
   기타the solvent removed by evaporation

실험 절차

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

출처