반응 #7574

반응 방정식

isopropanol

4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline

용매

2-pentanol

반응 조건

후처리

1. 1
   기타(prepared
2. 2
   온도was heated
3. 3
   온도at reflux for 7.5 hours
4. 4
   온도After cooling
5. 5
   여과the solid was filtered off
6. 6
   세척washed with isopropanol and ether
7. 7
   기타dried under vacuum

실험 절차

A suspension of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.2 g, 0.74 mmol), (prepared as described for the starting material in Example 2), and 2-fluoro-5-hydroxy-4-methylaniline (126 mg 0.89 mmol) in 2-pentanol (2.5 ml) was heated at reflux for 7.5 hours. After cooling, isopropanol was added and the solid was filtered off, washed with isopropanol and ether, and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (yellow solid 196 mg, 64%).

출처