반응 #75725

반응 방정식

2-methoxy-5-nitrobenzoic acid

cyclopropylmethylamine

N-hydroxybenzotriazole

EDC.HCl

sodium hydrogen carbonate

→

N-cyclopropylmethyl-2-methoxy-5-nitrobenzamide

용매

dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture stirred for 3 h
2. 2
   기타the precipitate collected as the title compound (6.95 g)

실험 절차

A solution of 2-methoxy-5-nitrobenzoic acid (4.9 g) (Rec. Trav. Chim. Pays-Bas, 1936, 737) and cyclopropylmethylamine (1.75 g) in dimethylformamide was treated with N-hydroxybenzotriazole (0.2 g) and EDC.HCl (4.74 g). The mixture was stirred for 24 h. Saturated sodium hydrogen carbonate was added, the mixture stirred for 3 h and the precipitate collected as the title compound (6.95 g). m/z (API+): 251 (MH+).

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