반응 #75718

반응 방정식

Sodium dithionite

1-methoxy-2-methylsulfanylmethyl-4-nitro-benzene

sodium hydrogen carbonate

→

title compound

수율 33.5%

4-Methoxy-3-methylsulfanylmethyl-phenylamine

수율 33.5%

용매

methanol water

반응 조건

후처리

1. 1
   기타Solvent was removed at reduced pressure
2. 2
   기타the residue partitioned between water and ethyl acetate
3. 3
   기타the organic phase separated
4. 4
   세척washed with brine
5. 5
   건조dried (Na2SO4) and solvent
6. 6
   기타removed at reduced pressure

실험 절차

Sodium dithionite (3.264 g) was added to a solution of 1-methoxy-2-methylsulfanylmethyl-4-nitro-benzene (0.8 g), and sodium hydrogen carbonate (1.57 g) in methanol:water (1:1, 200 ml) and stirred at room temperature for 16 h. Solvent was removed at reduced pressure, the residue partitioned between water and ethyl acetate, the organic phase separated, washed with brine dried (Na2SO4) and solvent removed at reduced pressure to give the title compound (0.23 g) as a brown oil. m/z (API+): 184 (MH+).

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