반응 #75717

반응 방정식

Sodium thiomethoxide

2-methoxy-5-nitrobenzyl bromide

→

title compound

수율 92.3%

1-Methoxy-2-methylsulfanylmethyl-4-nitro-benzene

수율 92.3%

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타solvent removed at reduced pressure
2. 2
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
3. 3
   세척washed with water and brine
4. 4
   건조dried (Na2SO4) and solvent
5. 5
   기타removed at reduced pressure

실험 절차

Sodium thiomethoxide (0.469 g) was added to a solution of 2-methoxy-5-nitrobenzyl bromide (1.5 g) in dimethylformamide (25 ml). The mixture was stirred for 16 h, solvent removed at reduced pressure and the residue dissolved in ethyl acetate and washed with water and brine, dried (Na2SO4) and solvent removed at reduced pressure to give the title compound (1.2 g) as a yellow solid

출처