반응 #75716

반응 방정식

compound

2-(4-methoxy-phenoxy)-5-nitro-benzoic acid methyl ester

hydrogen

→

title compound

수율 96.5%

5-Amino-2-(4-methoxy-phenoxy)-benzoic Acid Methyl Ester

수율 96.5%

용매

methanol

반응 조건

후처리

1. 1
   여과The mixture was filtered (kieselguhr) and solvent
2. 2
   기타removed from the filtrate under reduced pressure

실험 절차

The compound of step 1 (2.3 g) in methanol (150 ml) containing 10% Pd/C (0.5 g) was hydrogenated under one atmosphere of hydrogen for 18 h. The mixture was filtered (kieselguhr) and solvent removed from the filtrate under reduced pressure to give the title compound (2.0 g) as a yellow oil. 1H NMR (CDCl3) δ: 3.69 (2H, brs), 3.77 (6H, s), 6.76-6.87 (6H, m), 7.19 (1H, d, J=2.5 Hz).

출처