반응 #75715

반응 방정식

2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid

methanol

→

2-(4-methoxy-phenoxy)-5-nitro-benzoic acid methyl ester

반응 조건

후처리

1. 1
   기타Solvent was removed at reduced pressure
2. 2
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
3. 3
   세척washed with aqueous sodium hydrogen carbonate
4. 4
   건조The organic phase was dried (Na2SO4) and solvent
5. 5
   기타removed at reduced pressure

실험 절차

2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid (2.5 g), (DE 2058295) in methanol (75 ml) containing conc. sulfuric acid (3 drops) was boiled for 16 h. Solvent was removed at reduced pressure, the residue dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate. The organic phase was dried (Na2SO4) and solvent removed at reduced pressure to give 2-(4-methoxy-phenoxy)-5-nitro-benzoic acid methyl ester (2.50 g). m/z (API+): 304 (MH+).

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