반응 #7571

반응 방정식

4-chloro-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride

4-chloro-2-fluoro-5-hydroxyaniline

isopropanol

→

4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxy-7-(4-pyridylmethoxy)cinnoline

용매

2-pentanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux overnight
3. 3
   온도After cooling
4. 4
   기타The solid formed
5. 5
   여과was filtered off
6. 6
   세척washed with isopropanol, ether
7. 7
   기타dried under vacuum

실험 절차

A suspension of 4-chloro-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride (0.17 g, 0.45 mmol) and 4-chloro-2-fluoro-5-hydroxyaniline (102 mg, 0.63 mmol), (prepared as described in EP 061741 A2), in 2-pentanol (3.5 ml) was heated at reflux overnight. After cooling, isopropanol was added. The solid formed was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxy-7-(4-pyridylmethoxy)cinnoline as the hydrochloride salt (yellow solid, 194 mg, 86%).

출처