반응 #7565

반응 방정식

4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline

4-bromo-2-fluoroaniline

→

4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline

용매

DMF

반응 조건

후처리

1. 1
   온도After cooling to ambient temperature the mixture
2. 2
   workup.ADDITIONwas treated

실험 절차

A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.2 g, 0.74 mmol), (prepared as described for the starting material in Example 2), and 4-bromo-2-fluoroaniline (155 mg, 0.82 mmol) in DMF (2.5 ml) was heated at 150° C. for 45 minutes. After cooling to ambient temperature the mixture was treated as described in Example 3 to give 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (150 mg, 44%).

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