반응 #7549

반응 방정식

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol

L-tartaric acid

ethanol

→

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol L-tartrate

수율 91.8%

용매

ethyl acetate

ethyl acetate

반응 조건

후처리

1. 1
   workup.ADDITIONwere added
2. 2
   workup.DISSOLUTIONdissolution
3. 3
   workup.STIRRINGat the same temperature and the resulting mixture was stirred at 20 to 30° C. for 1 hour
4. 4
   기타The crystals precipitated
5. 5
   여과were collected by filtration

실험 절차

In 40 mL of ethyl acetate was dissolved 10.0 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol, and 5.15 g of L-tartaric acid and 40 mL of ethanol were added thereto, after which the resulting mixture was heated at 65° C. to effect dissolution. After the resulting solution was stirred at 50° C. for 20 minutes, 40 mL of ethyl acetate was added dropwise thereto at the same temperature and the resulting mixture was stirred at 20 to 30° C. for 1 hour. The crystals precipitated were collected by filtration to obtain 13.9 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol L-tartrate as colorless crystals.

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