반응 #7547

반응 방정식

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol

maleic acid

→

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate

수율 88.4%

용매

acetone

반응 조건

후처리

1. 1
   workup.ADDITIONby adding
2. 2
   workup.DISSOLUTIONdissolution
3. 3
   온도The reaction mixture was slowly cooled
4. 4
   기타The crystals precipitated
5. 5
   여과were collected by filtration

실험 절차

In 56 mL of acetone was dissolved 8.00 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol, followed by adding thereto 3.19 g of maleic acid, and the resulting mixture was heated at 60° C. to effect dissolution. The reaction mixture was slowly cooled and then stirred at 5° C. for 30 minutes. The crystals precipitated were collected by filtration to obtain 9.89 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate as colorless crystals.

출처