반응 #75429

반응 방정식

4-chloro-3-methylphenol

acetic anhydride

→

4-Chloro-3-methylphenyl Acetate

용매

water

반응 조건

후처리

1. 1
   기타equipped with a reflux condenser
2. 2
   추출The mixture was then extracted with 400 ml of diethyl ether
3. 3
   건조The organic phase was dried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe ether was distilled off
5. 5
   workup.DISTILLATIONThe raw product is subsequently distilled under reduced pressure (b.p. 65-68° C., 20 mbar)

실험 절차

43.0 g (0.30 mol) of 4-chloro-3-methylphenol, 34 ml (0.36 mol) of acetic anhydride and a few drops of concentrated sulfuric acid were stirred for 2 h at 60° C. in a 250 ml flask equipped with a reflux condenser. The reaction mixture was cooled to room temperature, poured into 200 ml of water and stirred for 1 h at room temperature. The mixture was then extracted with 400 ml of diethyl ether. The organic phase was dried over magnesium sulfate and the ether was distilled off. The raw product is subsequently distilled under reduced pressure (b.p. 65-68° C., 20 mbar).

출처