반응 #7542

반응 방정식

1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine

oxalic acid

→

1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine dioxalate

수율 89.6%

용매

ethyl acetate

ethyl acetate

반응 조건

후처리

1. 1
   workup.WAITat 5° C. for 1 hour
2. 2
   기타The crystals precipitated
3. 3
   여과were collected by filtration
4. 4
   세척washed with ethyl acetate
5. 5
   기타dried

실험 절차

In 3.0 mL of ethyl acetate was dissolved 0.71 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine, and to the solution was added a solution of 0.44 g of oxalic acid in 4.0 mL of ethyl acetate. The resulting mixture was stirred at room temperature for 1 hour and then at 5° C. for 1 hour. The crystals precipitated were collected by filtration, washed with ethyl acetate and then dried to obtain 1.03 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine dioxalate as colorless crystals.

출처