반응 #75410

반응 방정식

L-proline

sodium carbonate

3-(acetylthio)-2-(methylthiomethyl)propanoic acid chloride

acid

3-(acetylthio)-2-(methylthiomethyl)propanoic acid

thionyl chloride

→

1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONis added
2. 2
   추출After extraction with ethyl acetate
3. 3
   추출extracted with ethyl acetate
4. 4
   기타The organic layer is dried
5. 5
   농축concentrated to dryness in vacuo

실험 절차

To a solution of L-proline (1.44 g.) and sodium carbonate (2.7 g.) in water (25 ml.) in an ice bath, 3-(acetylthio)-2-(methylthiomethyl)propanoic acid chloride (prepared from the acid of Example 15 with thionyl chloride) (3.6 g.) is added, and the mixture is vigorously stirred at room temperature for two hours. After extraction with ethyl acetate, the aqueous layer is acidified and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness in vacuo to give 1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline.

출처