반응 #75408

반응 방정식

1-[3-(4-Methoxybenzylmercapto)-2-(methylthio)propanoyl]-L-proline tert-butyl ester

Trifluoromethanesulfonic acid

→

1-[3-mercapto-2-(methylthio)propanoyl]-L-proline

용매

dichloromethane

anisole

반응 조건

후처리

1. 1
   기타The solvent is removed in vacuo
2. 2
   세척The organic layer is washed six times with water
3. 3
   기타dried
4. 4
   농축concentrated to dryness in vacuo

실험 절차

1-[3-(4-Methoxybenzylmercapto)-2-(methylthio)propanoyl]-L-proline tert-butyl ester (0.5 g.) is dissolved in a mixture of dichloromethane (2 ml.) and anisole (1.1 ml.) under a blanket of argon in an ice bath. Trifluoromethanesulfonic acid (1 g.) is added and the mixture is stirred at room temperature for thirty minutes. The solvent is removed in vacuo and the residue is distributed between water and ethyl acetate. The organic layer is washed six times with water, dried and concentrated to dryness in vacuo to yield 1-[3-mercapto-2-(methylthio)propanoyl]-L-proline.

출처