반응 #75335

반응 방정식

potassium cyanide

ammonium carbonate

pyrano[3,2-h]quinolin-4-one

water

water

→

spiro[imidazolidin-4,4'-pyrano[3,2-h]quinolin]-2,5-dione

용매

ethanol

반응 조건

후처리

1. 1
   workup.WAITboiled for 20 minutes
2. 2
   추출The basic mixture was extracted with 3×50 ml chloroform
3. 3
   기타The solid obtained
4. 4
   여과after filtration
5. 5
   기타drying in vacuo (96 mg)
6. 6
   기타was twice recrystallized from ethanol

실험 절차

A solution of 0.500 g (2.51 mmol) of potassium cyanide and 0.280 g (4.27 mmol) of ammonium carbonate in 1.5 ml water was added to a solution of 130 mg (0.65 mmol) of pyrano[3,2-h]quinolin-4-one in 1.5 ml of ethanol at 60° C. The reaction mixture was held at this temperature for 72 hours then added to 20 ml of water and boiled for 20 minutes. The basic mixture was extracted with 3×50 ml chloroform and the mixture was acidified with 1 N hydrochloric acid. The solid obtained after filtration and drying in vacuo (96 mg) was twice recrystallized from ethanol yielding spiro[imidazolidin-4,4'-pyrano[3,2-h]quinolin]-2,5-dione, (36.0 mg), m.p. 305° C. (dec).

출처