반응 #75284

반응 방정식

4-chloro-2-fluoroaniline

cyclohexane-1,2-dicarboxylic anhydride

→

2-(4-chloro-2-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-isoindole-1,3(2H)dione

용매

acetic acid

반응 조건

후처리

1. 1
   온도After refluxing for 6 hours
2. 2
   workup.ADDITIONthe reaction mixture was poured into 200 parts of ice
3. 3
   여과The resulting crystals were filtered
4. 4
   기타recrystallized from 70 parts of methanol at -40°

실험 절차

9.44 parts of 4-chloro-2-fluoroaniline were then added to a solution of 10 parts of cyclohexane-1,2-dicarboxylic anhydride in 75 parts of glacial acetic acid. After refluxing for 6 hours, the reaction mixture was poured into 200 parts of ice. The resulting crystals were filtered and recrystallized from 70 parts of methanol at -40° to yield 12.4 parts of white crystals of 2-(4-chloro-2-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-isoindole-1,3(2H)dione melting at 94°-95.5°.

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