반응 #75201

반응 방정식

2-bromo-3-(4-methoxybenzylmercapto) propanoic acid

methylmercaptan

sodium hydroxide

→

3-(4-methoxybenzylmercapto)-2-(methylthio)propanoic acid

용매

ethanol

반응 조건

후처리

1. 1
   여과The sodium bromide is filtered off
2. 2
   농축the filtrate is concentrated to dryness in vacuo
3. 3
   workup.DISSOLUTIONThe residue is dissolved in water
4. 4
   추출extracted with ethyl acetate
5. 5
   기타The organic layer is dried
6. 6
   농축concentrated to dryness

실험 절차

A solution of 2-bromo-3-(4-methoxybenzylmercapto) propanoic acid (15 g.), methylmercaptan (3 g.) and sodium hydroxide (4.6 g.) in 95% ethanol (25 ml.) is refluxed for twelve hours. The sodium bromide is filtered off and the filtrate is concentrated to dryness in vacuo. The residue is dissolved in water, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness to yield 3-(4-methoxybenzylmercapto)-2-(methylthio)propanoic acid.

출처