반응 #7512

반응 방정식

ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

potassium carbonate

sodium iodide

4-methoxybenzyl chloride

→

title compound

수율 78.0%

Ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-methoxybenzyl)oxy]-5-pyrimidinecarboxylate

수율 78.0%

용매

water

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   여과The precipitated crystals were collected by filtration
3. 3
   세척washed several times with cold water and cold ether
4. 4
   기타dried

실험 절차

To a solution of ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (500 mg, 1.75 mmol) in N,N-dimethylformamide (10 mL) were added potassium carbonate (500 g, 4 mmol), sodium iodide (300 mg, 2 mmol) and 4-methoxybenzyl chloride (0.29 mL, 2 mmol), and the mixture was stirred at 80° C. for 18 h. The reaction mixture was allowed to cool to room temperature and water was added. The precipitated crystals were collected by filtration, washed several times with cold water and cold ether, and dried to give the title compound (550 mg, 78%).

출처