반응 #75085

반응 방정식

quinidine

fluorenone

sodium

→

quinidinone

용매

toluene

toluene

반응 조건

후처리

1. 1
   workup.ADDITIONby mixing 9 g
2. 2
   workup.ADDITIONTo this solution was added a hot solution of 37 g
3. 3
   온도After 15 minutes at reflux
4. 4
   추출After extraction and neutralization treatments as in Example I, 36 g

실험 절차

A solution of fluorenone ketyl was prepared by mixing 9 g. of fluorenone and 6.5 g. of sodium in anhydrous toluene. To this solution was added a hot solution of 37 g. of anhydrous quinidine base in 150 ml. of anhydrous toluene. After 15 minutes at reflux, the reaction was complete. After extraction and neutralization treatments as in Example I, 36 g. of pure quinidinone (TLC) was obtained (97% of theory).

출처