반응 #75030

반응 방정식

2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylic anhydride

3-phenoxybenzaldehyde

sodium cyanide

3-phenoxybenzaldehyde

→

alpha-cyano-3-phenoxybenzyl 2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylate

용매

water

반응 조건

후처리

1. 1
   기타A 100-ml round-bottomed flask equipped with a magnetic stirrer
2. 2
   기타prepared
3. 3
   기타of from 60° C. to 80° C
4. 4
   workup.STIRRINGAfter 100 minutes stirring
5. 5
   기타The mixture obtained
6. 6
   추출the aqueous layer was extracted with toluene (15 ml)
7. 7
   기타the extract phase obtained
8. 8
   workup.ADDITIONwas added to the organic layer
9. 9
   기타obtained
10. 10
    기타the organic liquid thus formed
11. 11
    세척was washed with water (25 ml)
12. 12
    기타the washed liquid was dried
13. 13
    기타the solvent was evaporated from the dried liquid
14. 14
    기타leaving a residue

실험 절차

A 100-ml round-bottomed flask equipped with a magnetic stirrer was charged with 2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylic anhydride (10 mmol), prepared as described above, 3-phenoxybenzaldehyde (10 mmol) and a mixture of alkanes (25 ml) having a boiling range of from 60° C. to 80° C. A solution of sodium cyanide (12 mmol) and tetrabutylammonium bromide (0.006 mmol) in water (3 ml) was added to the mixture in the flask at a temperature of 20° C. and stirring was continued. After 100 minutes stirring, the reaction had come to a standstill at a conversion of 3-phenoxybenzaldehyde of 98.5% and at a yield of the title ester of 98%. The mixture obtained was allowed to settle into an organic and an aqueous layer, the aqueous layer was extracted with toluene (15 ml), the extract phase obtained was added to the organic layer obtained by settling of the reaction mixture, the organic liquid thus formed, was washed with water (25 ml), the washed liquid was dried and the solvent was evaporated from the dried liquid, leaving a residue containing the title ester. The yield of this ester was 96%.

출처