반응 #74955

반응 방정식

2-(2-thienyl)ethylamine

hydrochloric acid

hexahydrotriazine

butylamine

→

4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride

수율 65.0%

용매

dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONis added, over 25 minutes
2. 2
   workup.ADDITIONa mixture of 17 g (0.2 M)
3. 3
   기타The desired product precipitates out at the end of the addition
4. 4
   여과Filtration

실험 절차

To 73 ml dimethylformamide heated at 45° C. in which are dissolved 0.45 mole gaseous hydrochloric acid, is added, over 25 minutes, a mixture of 17 g (0.2 M) s.hexahydrotriazine of n. n.butylamine/and 26 g 2-(2-thienyl)ethylamine. The temperature of the medium is maintained at 45° C. throughout the addition by means of a cold water bath. The desired product precipitates out at the end of the addition. Filtration gives 22.16 g 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (Yield: 65%).

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