반응 #74951

반응 방정식

2-(2-thienyl)ethylamine

chloromethylmethylether

chloromethylmethylether

→

4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine hydrochloride

수율 31.4%

용매

dimethylformamide

dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONare added, over 10 minutes
2. 2
   온도is then cooled to room temperature
3. 3
   기타The desired product precipitates out
4. 4
   세척is rinsed with acetone

실험 절차

To a solution of 12.7 g (0.1 M) 2-(2-thienyl)ethylamine in 20 ml dimethylformamide heated at 55° C. are added, over 10 minutes, 8.05 g (0.1 M) chloromethylmethylether diluted in 10 ml dimethylformamide. After addition of the chloromethylmethylether, the medium is maintained at 70° C. for 2 hours, and is then cooled to room temperature. The desired product precipitates out and is rinsed with acetone, to give 5.5 g 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine hydrochloride (M.p=225° C.; Yield: 31%).

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