반응 #748998

반응 방정식

5-fluoro-2-methylbenzoic acid

N-bromosuccinimide

→

2-(bromomethyl)-5-fluorobenzoic acid

수율 96.7%

용매

tetrachloromethane

반응 조건

후처리

1. 1
   여과The hot mixture was filtered
2. 2
   농축the filtrate was concentrated

실험 절차

Step 1 A suspension of 5-fluoro-2-methylbenzoic acid (500 mg, 3.24 mmol), N-bromosuccinimide (606 mg, 3.41 mmol) and benzoyl peroxide (47 mg, 0.195 mmol) in tetrachloromethane (10 mL) was heated at 78° C. for 4 h. The hot mixture was filtered and the filtrate was concentrated to provide crude 2-(bromomethyl)-5-fluorobenzoic acid as a white solid (730 mg), used without further purification. 1H NMR (400 MHz, chloroform-d) δ 7.81 (1H, dd, J=9.2, 2.9 Hz), 7.50 (1H, dd, J=8.5, 5.4 Hz), 7.23-7.30 (1H, m), 4.98 (2H, s).

출처