반응 #74897

반응 방정식

methanol

Compound 2

((5-Nitro-2-thiazolyl)thio)pyrazine 1-oxide

m-chloroperbenzoic acid

→

yellow crystals

수율 28.0%

((5-Nitro-2-thiazolyl)sulfinyl)pyrazine 1-oxide

수율 28.0%

용매

chloroform

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척The filtrate was washed with water, dilute bicarbonate and brine
3. 3
   건조dried over MgSO4
4. 4
   기타Evaporation of the solvent
5. 5
   기타afforded a yellow oil that solidified
6. 6
   기타This crude product was recrystallized from CHCl3 /hexane

실험 절차

To a stirred solution of 1.0 g (0.004 mol) of Compound 2 in 50 ml of chloroform was gradually added 2.0 g (0.010 mol) of 85% m-chloroperbenzoic acid. The reaction mixture was stirred overnight at room temperature and then filtered. The filtrate was washed with water, dilute bicarbonate and brine, and dried over MgSO4. Evaporation of the solvent afforded a yellow oil that solidified on standing. This crude product was recrystallized from CHCl3 /hexane and a second crop of crystals was recrystallized from methanol for a total yield of 0.3 g (28% yield) of yellow crystals, m.p. 139°-141° C.

출처