반응 #74857

반응 방정식

2,6-dimethylaniline

3-hydroxy-2-butanone

→

3-(2,6-dimethylphenylamino)-2-butanone

수율 94.4%

용매

benzene

반응 조건

후처리

1. 1
   온도under reflux for 21 hours in a reaction vessel
2. 2
   기타equipped with a Dean-Stark trap
3. 3
   온도The reaction mixture was then cooled
4. 4
   세척washed with four 600-ml portions of water
5. 5
   여과filtered
6. 6
   기타evaporated under reduced pressure

실험 절차

A solution of 484.8 g (4 mols) 2,6-dimethylaniline and 422.8 g (4.8 mols) 3-hydroxy-2-butanone in 1200 ml benzene was heated under reflux for 21 hours in a reaction vessel equipped with a Dean-Stark trap. The reaction mixture was then cooled, washed with four 600-ml portions of water, slurried with silica gel, filtered and evaporated under reduced pressure to give 722 g of 3-(2,6-dimethylphenylamino)-2-butanone, as an orange oil. The infrared spectrum of the product showed strong carbonyl absorption at 6.3 microns.

출처