반응 #74844

반응 방정식

2-(p-fluorobenzoyl)-3-dimethylaminocrotononitrile

HCl

methanol

→

2-(p-Fluorobenzoyl)-3-hydroxycrotononitrile

반응 조건

후처리

1. 1
   온도Upon cooling in an ice bath
2. 2
   기타a solid formed
3. 3
   기타was collected
4. 4
   기타recrystallized from cyclohexane-petroleum ether with charcoal treatment
5. 5
   기타giving 0.7 g

실험 절차

A solution of 1.35 g. (0.006 m) of 2-(p-fluorobenzoyl)-3-dimethylaminocrotononitrile in a mixture of 15 ml. methanol and 8 ml. of 1 N HCl was heated on the steam bath in an open beaker for 45 minutes. Upon cooling in an ice bath, a solid formed, was collected, and then recrystallized from cyclohexane-petroleum ether with charcoal treatment, giving 0.7 g. (64%) of light pinkish crystals, m.p. 65°-67° C.

출처