반응 #74791

반응 방정식

diborane

[9-methoxy-2-oxo-3,4,5,5a,6,7-hexahydro-2H-naphth-[1,2-d]azepin-1-yl]-N-isopropyl-acetamide

hydrochloric acid

→

1-(2-isopropylaminoethyl)-3,4,5,5a,6,7-hexahydro-9-methoxy-2H-naphth[1,2-d]azepin-2-one

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   온도the mixture is refluxed for one hour
2. 2
   workup.DISTILLATIONThe tetrahydrofuran is distilled off under reduced pressure
3. 3
   workup.ADDITIONthe remainder is diluted with water
4. 4
   여과The resulting precipitate is filtered off
5. 5
   추출re-extracted with hot water
6. 6
   세척The aqueous filtrate is washed with diethyl ether
7. 7
   추출The suspension is extracted with methylene chloride
8. 8
   기타the extract dried
9. 9
   기타evaporated
10. 10
    기타the residue recrystallized from acetone

실험 절차

80 ml of 1 M diborane in tetrahydrofuran are added to the suspension of 6.8 g of [9-methoxy-2-oxo-3,4,5,5a,6,7-hexahydro-2H-naphth-[1,2-d]azepin-1-yl]-N-isopropyl-acetamide in 100 ml of tetrahydrofuran while stirring under nitrogen at 0°. After 20 hours 60 ml of 3 N hydrochloric acid are added dropwise and the mixture is refluxed for one hour. The tetrahydrofuran is distilled off under reduced pressure and the remainder is diluted with water. The resulting precipitate is filtered off and re-extracted with hot water. The aqueous filtrate is washed with diethyl ether and basified with 3 N aqueous sodium hydroxide. The suspension is extracted with methylene chloride, the extract dried, evaporated and the residue recrystallized from acetone, to yield the 1-(2-isopropylaminoethyl)-3,4,5,5a,6,7-hexahydro-9-methoxy-2H-naphth[1,2-d]azepin-2-one melting at 147°-149°.

출처