반응 #74767
ord-d06799c8e7d2446093d305f30ce0c2ac
반응 방정식
시약
없음
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도the mixture was heated on a steam-bath for 0.5 hours
- 2여과The mixture was filtered
- 3농축concentrated
- 4추출extracted with chloroform
- 5추출the chloroform extract
- 6기타was evaporated
실험 절차
A solution of sodium nitrite (2.38 g) in water (10 ml) was added dropwise to a mixture of 3-amino-2-hydroxymethylpyridine (4.8 g), aqueous hydrochloric acid (48%, 10 ml) and water (5 ml) stirred at 0°-5°. This solution was added to a hot solution of cuprous chloride (2.5 g) in conc. hydrochloric acid and the mixture was heated on a steam-bath for 0.5 hours, diluted with water and saturated with hydrogen sulphide. The mixture was filtered, concentrated and extracted with chloroform and the chloroform extract was evaporated to give 3-chloro-2-hydroxymethylpyridine (3.7 g) m.p. 42°-44° (from n-pentane).