반응 #74764

반응 방정식

1-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride

potassium thiocyanate

→

2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate

용매

ethanol

반응 조건

후처리

1. 1
   기타The mixture was evaporated to dryness
2. 2
   추출extracted with chloroform
3. 3
   건조The chloroform extracts were dried (MgSO4)
4. 4
   기타evaporated to a residue which
5. 5
   기타was recrystallised from acetonitrile

실험 절차

1-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride (2.1 g) and potassium thiocyanate (0.97 g) were heated together under reflux in ethanol (50 ml) for 3 days. The mixture was evaporated to dryness and the residue was taken up in water, basified with sodium carbonate and extracted with chloroform. The chloroform extracts were dried (MgSO4) and evaporated to a residue which was recrystallised from acetonitrile to give 2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate m.p. 101°-103°. (Found: C, 45.3; H, 5.3; N, 19.5; S, 29.3. C8H11N3S2 requires: C, 45.0; H, 5.2; N, 19.7; S, 30.1%).

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