반응 #747483

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Ethyl 2-(4-amino-3-nitrophenyl)propanoate

→

Ethyl 2-(3,4-diaminophenyl)propanoate

용매

THF EtOH

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후처리

1. 1
   여과then filtered through celite bed
2. 2
   세척washed with EtOH
3. 3
   농축The filtrate was concentrated in vacuo
4. 4
   기타The residue was purified by flash column chromatography on silica gel

실험 절차

To the flask was added THF/EtOH (1:1, 50 mL) followed by Ethyl 2-(4-amino-3-nitrophenyl)propanoate (2.12 g, 8.90 mmol) and 10% palladium carbon (220 mg) at room temperature. The reaction mixture was hydrogenated and stirred for 3 hrs at 45 psi then filtered through celite bed, and washed with EtOH. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:4-1:2) as eluant.

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