반응 #74743

반응 방정식

DMSO

2-Chloro-5-nitropyridine

2,2,2-trifluoroethanol

lithium hydroxide

→

2-(2,2,2-Trifluoroethoxy)-5-Nitropyridine

용매

water

반응 조건

후처리

1. 1
   기타the product was separated by filtration
2. 2
   기타It was crystallized from ethyl acetate-hexanes, yield 5.0 grams
3. 3
   기타35°-37° C.

실험 절차

2-Chloro-5-nitropyridine (9.5 grams), 2,2,2-trifluoroethanol (6.0 grams), and lithium hydroxide (4.0 grams) were mixed in 50 ml. of DMSO and stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product was separated by filtration. It was crystallized from ethyl acetate-hexanes, yield 5.0 grams, m.p., 35°-37° C.

출처