반응 #747175

반응 방정식

imidate

4,6-Dichloro-2-ethoxymethyleneamino-3-methoxybenzoic acid methyl ester

hydrazine hydrate

→

3-amino-5,7-dichloro-8-methoxy-3H-quinazolin-4-one

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added under an argon atmosphere
2. 2
   여과filtered
3. 3
   세척The solid was washed with cold ethanol
4. 4
   기타dried under vacuum

실험 절차

To an ice-cooled solution of the imidate 5-2 (400 mg, 1.31 mmol) in ethanol (12 mL), was added under an argon atmosphere, hydrazine hydrate (1.8 mL, 57.8 mmol). After 15 min, the solution was warmed to room temperature and stirred for a further 2 h. The thick suspension was diluted with ethanol and filtered. The solid was washed with cold ethanol and dried under vacuum to give 3-amino-5,7-dichloro-8-methoxy-3H-quinazolin-4-one (5-3) as a white fluffy solid (289 mg, 85%).

출처