반응 #74568
ord-b083043d358544dcbd3734bbd645a5dc
반응 방정식
2-aminothiazole
pyridine
2,4-difluorobenzenesulfonyl chloride
→
2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축was concentrated
- 2기타purified by flash column chromatography
- 3세척eluting with hexane/ethyl acetate
실험 절차
To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+