반응 #74567
ord-b825268082ba4067a69655ff911ac4af
반응 방정식
2-aminothiazole
pyridine
3,4-difluorobenzenesulphonyl chloride
→
3,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출extracted with 1N HCl
- 2건조The organic layer was dried over sodium sulfate
- 3여과filtered
- 4농축concentrated
- 5기타The residue was purified by flash column chromatography
실험 절차
To a slurry of 2-aminothiazole (23.88 g, 0.2384 mol) in methylene chloride (150 mL) and pyridine (38.0 mL, 0.470 mol) was added dropwise a solution of 3,4-difluorobenzenesulphonyl chloride (25.0 g, 0.118 mol) in 10 mL of methylene chloride. After stirring for 48 hours the reaction was diluted with more dichloromethane and extracted with 1N HCl. The organic layer was dried over sodium sulfate, filtered, and concentrated. The residue was purified by flash column chromatography to give 3,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide as a white solid. LCMS Rt=1.24 minutes MS m/z 277 [MH]+