반응 #745303

반응 방정식

metformin

glutaric acid

ethyl acetate

→

metformin glutarate

수율 65.9%

용매

methyl alcohol

반응 조건

후처리

1. 1
   여과The produced crystal was filtered
2. 2
   기타dried in hot air

실험 절차

10.0 g of the metformin free-base and 3.98 g of glutaric acid were stirred in 100 ml of methyl alcohol at a temperature of 40° C., and then ethyl acetate was added thereto. The produced crystal was filtered and dried in hot air, thus obtaining 5.15 g (yield: 43.8%) of metformin glutarate.

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