반응 #74507

반응 방정식

5-bromo-2-chloro-4-methoxybenzonitrile

NaOH

EtOH

→

title compound

5-Bromo-2-chloro-4-methoxybenzoic acid

용매

water

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   기타EtOH was removed under reduced pressure
3. 3
   workup.ADDITIONThe mixture was diluted with water and neutralized with hydrochloric acid (3.0 N)
4. 4
   여과The resulting solid was filtered
5. 5
   기타dried in vacuo

실험 절차

A mixture of 5-bromo-2-chloro-4-methoxybenzonitrile (30.7 g, 124 mmol) and NaOH (127 g, 3.11 mol) in EtOH (500 mL) and water (250 mL) was refluxed overnight. After cooling to room temperature, EtOH was removed under reduced pressure. The mixture was diluted with water and neutralized with hydrochloric acid (3.0 N). The resulting solid was filtered and dried in vacuo to give title compound (32.9 g, quantitative) as a white solid.

출처