반응 #74503

반응 방정식

water

2,4-dichlorobenzoic acid

compound 80

2,4-dichlorobenzoic acid

bromine

→

title compound

수율 187.5%

5-Bromo-2,4-dichlorobenzoic acid

수율 187.5%

용매

chlorosulfonic acid

반응 조건

후처리

1. 1
   온도cooled to ambient temperature
2. 2
   기타The resulting solid was isolated by filtration
3. 3
   기타dried in vacuo

실험 절차

To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.

출처