반응 #74496

반응 방정식

4-bromo-1-hydroxy-2-naphthoic acid

compound 67

4-bromo-1-hydroxy-2-naphthoic acid

dimethyl sulfate

K2CO3

→

title compound

수율 78.6%

Methyl 4-bromo-1-methoxy-2-naphthoate

수율 78.6%

용매

acetone

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   여과The solid was filtered
3. 3
   기타condensed
4. 4
   기타to give a solid residue, which
5. 5
   기타was recrystallized from EtOAc/hexanes

실험 절차

A mixture of 4-bromo-1-hydroxy-2-naphthoic acid (compound 67, 24.7 g, 92.2 mmol), dimethyl sulfate (21.8 mL, 231 mmol), and K2CO3 (31.9 g, 231 mmol) in acetone (200 mL) was refluxed overnight. The solid was filtered, and the filtrate was condensed to give a solid residue, which was recrystallized from EtOAc/hexanes to afford the title compound (21.4 g, 78%) as a white solid.

출처