반응 #74383

반응 방정식

(1R,2S,4R)-5,5-difluorobicyclo[2.2.1]heptan-2-ol

pyridinium chlorochromate

→

title compound

(1R,4R)-5,5-Difluorobicyclo[2.2.1]heptan-2-one

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   온도The reaction mixture was warmed to ambient temperature
2. 2
   여과filtered through a pad of silica gel
3. 3
   기타Removal of the solvents

실험 절차

Silica gel 60 (particle size, 0.040-0.063 mm, CAS # 63231-67-4, from EMD Chemical Inc. 4.0 g) was added to a solution of (1R,2S,4R)-5,5-difluorobicyclo[2.2.1]heptan-2-ol (0.800 g, 5.40 mmol) in anhydrous dichloromethane (20.0 ml). The mixture was cooled to 0° C., and pyridinium chlorochromate (1.86 g, 8.64 mmol) was added. The reaction mixture was warmed to ambient temperature and stirred at this temperature overnight. After this time, the mixture was diluted with dichloromethane (30 mL) and then filtered through a pad of silica gel. Removal of the solvents gave the title compound as a white solid.

출처