반응 #74280

반응 방정식

1-(pyridin-4-yl)piperazine

N-benzyl-piperidinone

KCN

AcOH

→

1-Benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidine-4-carbonitrile

수율 47.0%

용매

methanol

water

반응 조건

후처리

1. 1
   기타The reaction mixture was quenched with NH4OH solution (400 ml)
2. 2
   여과filtered
3. 3
   세척The solid precipitate was thoroughly washed with water
4. 4
   기타dried under vacuum
5. 5
   기타taken through to the next reaction without further purification

실험 절차

A solution containing 1-(pyridin-4-yl)piperazine (58.34 mmol, 1 equiv.), N-benzyl-piperidinone (1 equiv.), KCN (1.1 equiv.), AcOH (3.3 ml) and water (1.3 ml) in methanol was stirred at room temperature for 16 h. The reaction mixture was quenched with NH4OH solution (400 ml) and filtered. The solid precipitate was thoroughly washed with water, dried under vacuum and taken through to the next reaction without further purification. Yield: 47%.

출처