반응 #7428

반응 방정식

diisopropyl azodicarboxylate

4-bromo-2-fluorophenol

1-butanol

triphenylphosphine

→

compound ( 2 )

수율 95.6%

1-bromo-3-fluoro-4-butoxybenzene

수율 95.6%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타the solvent was removed by distillation in a rotary evaporator

실험 절차

0.315 mol of each of 4-bromo-2-fluorophenol (1), 1-butanol and triphenylphosphine were dissolved in 1000 ml of tetrahydrofuran, and 0.315 mol of diisopropyl azodicarboxylate was added dropwise at about 20° C. After the mixture had been stirred overnight, the solvent was removed by distillation in a rotary evaporator, and the residue was subjected to conventional work-up, giving the compound (2) in a yield of 95.6% of theory.

출처