반응 #74274

반응 방정식

N-((1-benzyl-4-(4-cyclopropylpiperazin-1-yl)-piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

acetic acid

hydrogen

→

desired product

수율 90.0%

N-((4-(4-Cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

수율 90.0%

용매

methanol

반응 조건

후처리

1. 1
   기타for 10 min
2. 2
   여과The reaction mixture was filtered through celite
3. 3
   농축the filtrate was concentrated to dryness

실험 절차

Through a solution of N-((1-benzyl-4-(4-cyclopropylpiperazin-1-yl)-piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide (5.4 mmol) in methanol (30 ml) was passed argon gas for 10 min. Then acetic acid (855 μl) and Pd(OH)2 (40% by weight) were added to the reaction mixture and it was stirred at room temperature for 16 h under an atmosphere of H2 by using a hydrogen balloon. The reaction mixture was filtered through celite and the filtrate was concentrated to dryness to yield the desired product which was used in the next step without further purification. Yield: 90%.

출처