반응 #74272

반응 방정식

1-benzylpiperidin-4-one

acetic acid

N-cyclopropyl piperazine

potassium cyanide

→

desired product

수율 53.0%

1-Benzyl-4-(4-cyclopropylpiperazin-1-yl)piperidine-4-carbonitrile

수율 53.0%

용매

methanol

water

반응 조건

후처리

1. 1
   기타The resulting reaction mixture
2. 2
   기타had separated
3. 3
   여과The solid was collected by filtration
4. 4
   세척washed with water
5. 5
   기타dried

실험 절차

To a solution of 1-benzylpiperidin-4-one (26.42 mmol, 1.0 equiv.) and acetic acid (26.42 mmol, 1.0 equiv.) in methanol (10 ml) were added water (600 ml), N-cyclopropyl piperazine (29.06 mmol, 1.1 equiv.), and potassium cyanide (26.42 mmol, 1.0 equiv.). The resulting reaction mixture was stirred at room temperature for 1 h by which time a solid had separated. The solid was collected by filtration, washed with water and dried to obtain the desired product which was used in the next step without further purification. Yield: 53%.

출처