반응 #74237

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N-(4-ethylbenzyl)benzimidazol-5-amine

2,3,5,6-tetrafluoro-4-methylbenzylbromide

K2CO3

→

N-(2,3,5,6-Tetrafluoro-4-methylbenzyl)-N-(4-ethylbenzyl)-1H-benzo[d]imidazol-5-amine

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후처리

1. 1
   기타The compound was synthesized
2. 2
   기타rt 19.03 min (93.3%)

실험 절차

The compound was synthesized starting from N-(4-ethylbenzyl)benzimidazol-5-amine (251 mg; 1 mmol; 1 eq.), 2,3,5,6-tetrafluoro-4-methylbenzylbromide (283 mg; 1.1 mmol; 1.1 eq.) and K2CO3 (152 mg; 1.1 mmol; 1.1 eq.) according to method 6; Yield: 0.051 g (11.9%); MS m/z: 428.4 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.11 (t, 3H, 3J=7.6 Hz); 2.18 (s, 3H); 2.50-2.54 (m, 2H); 4.47 (s, 2H); 4.70 (s, 2H); 6.87-6.91 (m, 2H); 7.07 (d, 2H, 3J=7.9 Hz); 7.14 (d, 2H, 3J=7.9 Hz); 7.37 (d, 1H, 3J=8.9 Hz), 7.96 (s, 1H); 12.05 (br s, 1H); HPLC (METHOD [A]): rt 19.03 min (93.3%)

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