반응 #742252

반응 방정식

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

dec-9-en-1-ol

→

colourless crystals

수율 21.5%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid dec-9-enyl ester

수율 21.5%

용매

ether

반응 조건

후처리

1. 1
   기타removing the ethanol
2. 2
   기타formed
3. 3
   온도the reaction mixture was cooled
4. 4
   세척washed with brine
5. 5
   기타The organic phase was dried
6. 6
   기타evaporated to dryness
7. 7
   workup.DISTILLATIONThe resulting oil was Kugelrohr-distilled
8. 8
   기타crystallized
9. 9
   기타recrystallized

실험 절차

A mixture of 5.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester, 6.1 g dec-9-en-1-ol and 1.0 g tetraisopropyl-ortho-titanate was heated to 150° C. removing the ethanol formed. After stirring for 2.5 hours at this temperature, the reaction mixture was cooled, diluted with ether and washed with brine. The organic phase was dried and evaporated to dryness. The resulting oil was Kugelrohr-distilled, crystallized and recrystallized to yield 1.69 g of colourless crystals.

출처