반응 #742251

반응 방정식

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

potassium hydroxide

→

colourless crystals

수율 51.9%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid

수율 51.9%

용매

ethanol

water

반응 조건

후처리

1. 1
   온도at reflux for 28 hours
2. 2
   농축the reaction mixture was concentrated
3. 3
   workup.ADDITIONThe residue was diluted with 500 ml HCl 2N
4. 4
   추출extracted with ether
5. 5
   세척The organic phase was washed with 2N HCl and water
6. 6
   기타dried
7. 7
   기타evaporated to dryness
8. 8
   기타The resulting solid was recrystallized

실험 절차

To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.

출처