반응 #742249

반응 방정식

ethoxycarbonylmethylenetriphenylphosphorane

toluene

1-(4-diethylamino-2-hydroxy-phenyl)ethanone

→

3(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester

반응 조건

후처리

1. 1
   온도Then the reaction mixture was heated to reflux
2. 2
   온도After refluxing for 31 hours the mixture
3. 3
   온도was cooled down
4. 4
   기타evaporated to dryness
5. 5
   기타The resulting dark oil was purified by chromatography
6. 6
   기타to yield a colourless oil

실험 절차

To a suspension of 5.27 g ethoxycarbonylmethylenetriphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.

출처